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wrotek
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Posted: Sun May 25th, 2008 14:28 |
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Maybe worth mentioning.
http://tinyurl.com/48u7x7
The Flavonoid Apigenin Suppresses Vitamin D Receptor Expression and Vitamin D Responsiveness in Normal Human Keratinocytes
http://en.wikipedia.org/wiki/Apigenin
Apigenin is a flavone that is the aglycone of apiin, isolated from parsley and celery, and apigetrin. It is a yellow crystalline solid that has been used to dye wool.
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Lyme reflux chronic pain fatigue depression 125D36 Ph1Sep05 Ph2Oct06 Ph3Apr07 homebound in low lux NoIRs 25D<7 Oct06
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Phillyguy
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Posted: Sun May 25th, 2008 19:18 |
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Resveratrol upregulates dose-dependently the expression of 1,25(OH)(2)D-3 nuclear receptor.
Resveratrol inhibits myeloma cell growth and promotes healthy bone marrow
According to recent research from Denmark, Multiple myeloma is characterized by the accumulation of clonal malignant plasma cells in the bone marrow, which stimulates bone destruction by osteoclasts and reduces bone formation by osteoblasts. In turn, the changed bone microenvironment sustains survival of myeloma cells. Therefore, a challenge for treating multiple myeloma is discovering drugs targeting not only myeloma cells but also osteoclasts and osteoblasts.
"Because resveratrol is reported to display antitumor activities on a variety of human cancer cells," wrote P. Boissy and colleagues at South Denmark University Network in Vejle, "we investigated the effects of this natural compound on myeloma and bone cells. We found that resveratrol reduces dose-dependently the growth of myeloma cell lines (RPMI 8226 and OPM-2) by a mechanism involving cell apoptosis."
In cultures of human primary monocytes, resveratrol inhibits dose-dependently receptor activator of nuclear factor-kappa B (NF-kappa B) ligand-induced formation of tartrate-resistant acid phosphatase (TRACP)-positive multinucleated cells, TRACP activity in the medium, upregulation of cathepsin K gene expression, and bone resorption, scientists reported.
These inhibitions are associated with a downregulation of RANK expression at both mRNA and cell surface protein levels and a decrease of NFATc1 stimulation and NF-kappa B nuclear translocation, whereas the gene expression of c-fins, CD14, and CD11a is upregulated, the authors said.
Finally, resveratrol promotes dose-dependently the expression of osteoblast markers like osteocalcin and osteopontin in human bone marrow mesenchymal stem cells (hMSC-TERT) and stimulates their response to 1,25(OH)(2) vitamin D-3 [1,25(OH)(2)D-3].
"Moreover," Boissy continued, "resveratrol upregulates dose-dependently the expression of 1,25(OH)(2)D-3 nuclear receptor."
Researchers concluded, Taken together, these results suggest that resveratrol or its derivatives deserve attention as potential drugs for treating multiple myeloma.
Source:
Boissy, et.al. Resveratrol inhibits myeloma cell growth, prevents osteoclast formation, and promotes osteoclast differentiation. Cancer Res, 2005;65(21):9943-9952).
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wrotek
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Posted: Mon May 26th, 2008 05:00 |
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Novel class of vitamin D receptor modulator (see page 343 of the document)
http://tinyurl.com/4fgjr7
Dermatologic drugs Researchers at Lilly and the University of Tokyo have identified a novel class of vitamin D receptor mod-ulators with therapeutic potential in the treatment of psoriasis. LY- 2108491 and LY-2109866 are two nonsecosteroidal vitamin D receptor (VDR) ligands that were investigated in vitro and also in vivo in a surrogate model of psoriasis. Both compounds were characterized as potent VDR ligands since they promoted heterodimerization of VDR with RXR (retinoid X receptor) with EC50 values of 11 nM for LY-2108491 and 13 nM for LY-2109866, in a ligand sensing assay in SaOS-2 cells. Both compounds were more potent inhibitors of keratinocyte proliferation than calcitriol, and induced the expression of vitamin D-responsive genes in keratinocytes, but not in intestinal cells, as effectively as calcitriol. In vivo, these two VDR modulators decreased Th1 cytokine response, by reducing the expression of proinflammatory cytokines interferon gamma and interleukin- 2.Agents that inhibit keratinocyte proliferation in psoriatic lesions have also been shown to induce epidermal proliferation in normal skin. Based to this rationale, LY- 2108491 and LY-2109866 were applied topically to hairless mice, where these compounds increased epidermal thickness with a higher therapeutic index than calcitriol. Interestingly, VDR modulating agents did not cause epidermal proliferation in VDR-defective mice. Furthermore, both topical and oral administration of these VDR modulators did not cause hypercalcemia compared with calcitriol, indicating a better safety profile (Ma, Y. et al. J Clin Invest 2006, 116(4): 892).
Last edited on Mon May 26th, 2008 05:07 by wrotek
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wrotek
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Posted: Tue May 27th, 2008 19:22 |
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Plant Flavonoid In Celery And Green Peppers Found To Reduce Inflammatory Response In The Brain
http://www.sciencedaily.com/releases/2008/05/080520094115.htm
this is luteolin
And this is apigenin, compond found also in celery i have mentioned few posts before.
Are not they very similar ?
Last edited on Tue May 27th, 2008 19:23 by wrotek
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Lyme reflux chronic pain fatigue depression 125D36 Ph1Sep05 Ph2Oct06 Ph3Apr07 homebound in low lux NoIRs 25D<7 Oct06
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NickBowler
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Posted: Fri Jun 13th, 2008 15:06 |
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How about this - you might not even need to drink the stuff to alter gene expression!
'DRINKING a cup of coffee can wake you up, but perhaps just a whiff of Java is enough to reverse the effects of sleep deprivation on the brain. A team led by Yoshinori Masuo at the National Institute of Advanced Industrial Science and Technology in Tsukuba, Japan, deprived rats of sleep for a day. When they examined their brains they found reduced levels of mRNA - messenger molecules that indicate when a gene is being expressed - for 11 genes important to brain function. When the rats were exposed to the aroma of coffee, the mRNA for nine of the genes was restored to near normal levels, and pushed to above normal levels for two - GIR, involved in neuro-endocrine control, and NFGR, thought to control oxidative stress (Journal of Agricultural and Food Chemistry, DOI: 10.1021/jf8001137).
We don't know if the same genes are suppressed in sleep-deprived humans, nor whether we would feel tired if they were, but many of these genes do have human equivalents. So the team says gene suppression may help explain why people feel bad when they haven't had enough sleep - and that gene reactivation could explain why people love the smell of coffee.
Next the team hopes to identify the molecules in coffee aroma that affect gene expression. They suggest pumping them into factories to help revive tired workers who can't sip coffee while operating machinery.'
From issue 2660 of New Scientist magazine, 13 June 2008, page 16
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Sarcoirodis CIDP, MP start 11/07, NoIRs, 02/08 25D-8, Ph3 since 07/08|
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Dr Trevor Marshall
Research Team
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Posted: Fri Jun 13th, 2008 15:55 |
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At least these scientists are contemplating the possibility that their rat genes may not have human equivalents.
That is the degree of precision which Biology now enjoys, as long as the researchers are smart enough to comprehend that mice and men are not 100% equals
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wrotek
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Posted: Sun Jun 15th, 2008 08:47 |
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http://tinyurl.com/52ubaq
Novel Nutritional Ligands for VDR
VDR also selectively binds certain omega3/omega6 polyunsaturated fatty acids (PUFAs) with low affinity, leading to transcriptionally active VDR-RXR complexes. Moreover, the turmeric-derived polyphenol, curcumin, activates transcription of a VDRE reporter construct in human colon cancer cells. Activation of VDR by PUFAs and curcumin may elicit unique, 1,25(OH)(2)D(3)-independent signaling pathways to orchestrate the bioeffects of these lipids in intestine, bone, skin/hair follicle, and other VDR-containing tissues.
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Lyme reflux chronic pain fatigue depression 125D36 Ph1Sep05 Ph2Oct06 Ph3Apr07 homebound in low lux NoIRs 25D<7 Oct06
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jarjar
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Posted: Sun Jun 15th, 2008 18:28 |
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I read about this a couple of months ago and wasn't sure if this has ever been brought up on the board. Its about Green Tea Boosting Antibiotics.
If the topic has already been addressed my apologies.
http://www.healthfinder.gov/news/newsstory.asp?docid=614042
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Lyme/CFS for 18 years. Feet Neuropathy, tinninitus,cognitive difficulties.
10/04 vita D 47 vita d 1.25 36
02/05 vita D 31 vita d 1.25 39
08/06 vita D 20 vita d 1.25 49
11/06 vita D 13
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wrotek
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Posted: Sun Jun 15th, 2008 20:30 |
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I have been wondering about this green tea antibiotic boosting effect myself.
But i am afraid this is only an in-vitro work, and also they don't know how it works.
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wrotek
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Posted: Mon Jun 16th, 2008 05:39 |
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4-Caffeoyl-1,5-quinide in roasted coffee inhibits [ 3H]naloxone binding and reverses anti-nociceptive effects of morphine in mice
http://www.springerlink.com/content/e8ttltnn13015lbc/
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jlunn247
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Posted: Mon Jun 16th, 2008 12:54 |
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I agree based upon personal experience.
I had two boxer dogs who both developed similar symptoms to my disorders.
I did try to treat my last surviving dog but the protocol was too much for her.
She did respond initially and I watched her start to get better.
But I could not afford the benicar. She had some nervous system repair.
Except her hip muscles still atrophied.
I know now that her dose of benicar was too low and not frequent enough.
her bladder & bowel control stayed normal even to the day I euthanised her.
Her untreated mother lost bladder control at the end.
I am very proud of her treated daughter she gave me lots of hope for my own recovery.
She was the smartest bravest and toughest dog I ever knew.
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Sarc/lungs/joint pain TMJnerve pain 125D56 25D16 Ph1Mar07 ModPh2Jun07 Ph2Nov07 PHase3Feb08 albuterol
dark sunglasses hands & face exposed. Medium herx
mostly.june09
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NickBowler
Member in Phase 3
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Posted: Tue Jun 17th, 2008 12:26 |
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http://www.newscientist.com/channel/health/dn14151-guzzling-coffee-may-cut-heart-disease.html?feedId=online-news_rss20
Journal reference: Annals of Internal Medicine (vol 148, p 913)
A strong cup of coffee in the morning can feel like a life saver. Now, one of the largest and longest studies of coffee drinking suggests that coffee may indeed boost your lifespan – providing you drink enough of the stuff, that is.
The study tracked 129,000 men and women over two decades. It found that people who consumed several cups of coffee every day were less likely to die of heart disease than those who shied away from the stuff. Heart disease is an umbrella term for conditions including heart attacks, stroke, and arrhythmia.
The researchers found that women who drank four to five cups per day were 34% less likely to die of heart disease, while men who had more than five cups a day were 44% less likely to die.
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Sarcoirodis CIDP, MP start 11/07, NoIRs, 02/08 25D-8, Ph3 since 07/08|
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Dr Trevor Marshall
Research Team
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Posted: Tue Jun 17th, 2008 17:59 |
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Heck, Nick, you would have to be fit and healthy to cope with more than 5 cups a day. One cup of the stuff used to make me sick. How is it possible the investigators didn't think of that
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Markt9452
Member in Phase 3
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Posted: Tue Jun 17th, 2008 18:20 |
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Trevor - You have to "Guzzle" the Coffee - You probably weren't drinking it fast enough.
mt
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Th1 Lyme Symptoms 125D20 D2510 Ph1Feb08 Ph2Apr08 Ph3Oct08 daily med.exp covered up NoIRs| MyStory|
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Carricol
Member in Phase 3
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Posted: Wed Jun 18th, 2008 04:33 |
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| Five cups is nothing. I used to drink more than that. Sometimes I would have the 5 cups by mid-morning. I knew others in the past that drank that much or more also.
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Sarcoidosis 1-25D 16, 21 Oct 08; Ph1 Nov07, Synthroid, 5-HTP, tyrosine, digestive enzymes, NOIRs lite exp r/t commute cover up, Ph2 Jan 08, Ph 3, 6 May 09, 25D 5, Jul 09
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Chris
Moderator
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Posted: Wed Jun 18th, 2008 22:35 |
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Count me among the coffee guzzlers. I always amazed my wife in being able to drink coffee right up until bedtime and still be able to sleep soundly. I thought it was a genetic ability among those of scandinavian descent.
A morning cup is still the fastest and most reliable way of clearing the morning herx.
- Chris
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sarcoid diagnosed 1991, probably started 1983
D25/1,25: Mar04 17/80, Sep04 12/50, Nov04 8/23, Jan05 9/39 May05 6/27; in phase3; fevers, muscle pain, tinnitus, depression, mental-fog, IBS, carpal-tunnel, fatigue, osteopenia
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Markt9452
Member in Phase 3
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Posted: Thu Jun 19th, 2008 04:13 |
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I really like Coffee but I have noticed that in the last week or so it makes me feel bad when I drink it. It upsets my stomach and I feel generally uncomfortable after a cup.
Makes it easier to cut back though.
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Th1 Lyme Symptoms 125D20 D2510 Ph1Feb08 Ph2Apr08 Ph3Oct08 daily med.exp covered up NoIRs| MyStory|
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jr_md
Health Professional
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Posted: Thu Jun 19th, 2008 07:54 |
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Just don't overdo the tea either.
Read this from the Mayo clinic
http://www.mayoclinicproceedings.com/pdf%2F8206%2F8206briefreport.pdf
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marion villa
Member in Phase 3
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Posted: Fri Jun 20th, 2008 05:25 |
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guys:
being with a batman suit, staying at home,avoiding light, not eating eggs, no beer either,hasn´t been sooo tough as not drinking my beloved coffee!!!
I must confess I drink a cup, when it is very desired. . and I doesnt feel anything odd...
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wrotek
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Posted: Sat Jun 21st, 2008 03:41 |
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Chlorogenic acid compounds from coffee are differentially absorbed and metabolized in humans.
http://www.ncbi.nlm.nih.gov/pubmed/17884997
Chlorogenic acids (CGA) are abundant phenolic compounds in coffee, with caffeoylquinic (CQA), feruloylquinic (FQA), and dicaffeoylquinic (diCQA) acids being the major subclasses. Despite the potential biopharmacological properties attributed to these compounds, little is known about their bioavailability in humans. In this study, we evaluated the distribution profile of the major CGA isomers and metabolites in plasma and urine of 6 healthy adults for 4 h after brewed coffee consumption. Three CQA isomers and 3 diCQA isomers were identified in the plasma of all subjects after coffee consumption, whereas 2 FQA were identified in only 1 subject. Two plasma concentration peaks were observed, the first at 0.5-1.0 h and the second at 1.5-4.0 h after coffee consumption. The molar ratio CQA:diCQA was 12.2 in the brewed coffee, whereas in plasma it ranged from 0.6-2.9. The molar ratios 5-CQA:3-CQA and 5-CQA:4-CQA were consistently higher in plasma than in the brew. The main CGA metabolites identified in urine after coffee consumption were: dihydrocaffeic, gallic, isoferulic, ferulic, vanillic, caffeic, 5-CQA, sinapic, rho-hydroxybenzoic, and rho-coumaric acids (gallic and dihydrocaffeic acids being the major ones). This study indicates that the major CGA compounds present in coffee are differentially absorbed and/or metabolized in humans, with a large inter-individual variation. Moreover, urine does not appear to be a major excretion pathway of intact CGA compounds in humans. PMID: 17884997 [PubMed - indexed for MEDLINE
Perhaps this can me useful.
Last edited on Sat Jun 21st, 2008 04:04 by wrotek
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Lyme reflux chronic pain fatigue depression 125D36 Ph1Sep05 Ph2Oct06 Ph3Apr07 homebound in low lux NoIRs 25D<7 Oct06
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