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sunflower
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Posted: Fri Jan 25th, 2008 19:42 |
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i have taken diflucan in the past, two separate times (100 mg day/or qod), for many months to treat chronic candidiasis....i always felt so horrible while on it. i just assumed it was massive herxing from the dying off of the yeast, but maybe something alot more sinister was going on  . other than suppressing the immune system and allowing the l-form bacteria to proliferate, do you think the drug could have caused permanent damage to my body? thanks....sunLast edited on Fri Jan 25th, 2008 21:34 by sunflower
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Carricol
Member in Phase 2
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Posted: Sun Jan 27th, 2008 02:44 |
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| Back to the coffee issue. There are a number of specialty coffees that are advertized as low acid. Does anyone know if these are low in chlorogenec acid or have the majority of the chlorogenec acid removed?
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Sarcoidosis 1-25D 16, 21 Oct 08; Ph1 Nov07, Synthroid, 5-HTP, tyrosine, digestive enzymes, NOIRs lite exp r/t commute cover up, Ph2 Jan 08 25D 7 Oct 08
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wrotek
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Posted: Sun Jan 27th, 2008 02:53 |
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I think there is an important question to ask, what is more disturbing for VDR metabolism in coffee, high chlorogenic acid content (which exhibits VDR antagonism) or cafestol (PXR, FXR agonist, most potent cholesterol elevating factor known to men).
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Lyme reflux chronic pain fatigue depression 125D36 Ph1Sep05 Ph2Oct06 Ph3Apr07 homebound in low lux NoIRs 25D<7 Oct06
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wrotek
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Posted: Thu Jan 31st, 2008 01:38 |
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Hmmm and another thing. One can buy a decaffeinated coffee and pour it through a paper filter, to get rid of cafestol. So now one has a decaffeinated and decafestolated coffee, with a sour taste - from the lack of the lipid content.
So is it enough to get rid of all measurable effects that coffee exerts on human body ? Well, apparently not, because study linking inflammatory markers rise and moderate coffee drinking includes also a decafeinated -filtered coffee, so if not chlorogenic acid, then there is something else in coffee, that rises inflammatory markers.
Last edited on Thu Jan 31st, 2008 01:53 by wrotek
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Lyme reflux chronic pain fatigue depression 125D36 Ph1Sep05 Ph2Oct06 Ph3Apr07 homebound in low lux NoIRs 25D<7 Oct06
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tickbite
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Posted: Fri Feb 1st, 2008 17:28 |
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How about this Wrotek........don't drink coffee and sweat the recovery.......we all know you love coffee. It's time to let go 
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"Lyme","CFS", Meningitis
Phase3 8-2-07, MP on hold 11/2007
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Knochen
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Posted: Fri Feb 1st, 2008 17:30 |
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If I can quit coffee, anybody can. I think I put Juan Valdez's kids through college!
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wrotek
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Posted: Fri Feb 1st, 2008 23:05 |
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jcwat101
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Posted: Sat Feb 2nd, 2008 19:41 |
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Lately, I have been trying a little caffeine from a pill (No Doze).
I use about 1/4 when I get up and about 1/4 at noon. The total is the amount in a cup of coffee (100 mg). I find it helpful for alertness and perhaps mood and don't detect any sign it affects my immunopathology (based on a variety of symptoms).
I used to think caffeine made me shakey (at least above a certain level), but this amount seems fine and there is no worry about all the other ingredients in coffee or tea. I also saw caffeine supplements sold online (don't know if they have No Doze type things in the stores in Poland).
Joyce Waterhouse
PS Nov. 2008 note: I have stopped caffeine. See Nov. 12, 2008 post in my progress report for my thoughts on my experiment with taking it:
Joyce's good progress on MP - Phase One Alumni Forum - PROGRESS REPORTS page 3Last edited on Wed Nov 12th, 2008 23:07 by jcwat101
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20 yrs with CFS/FM/Lyme/IBS, food sensitivities; 1,25D/25D 8/04:64/11 1/05:22/6 9/05:1,25D=12 10/06:22/8, 4/07:25/<4 chewed Ben. 40mg q8h; Mod. P2: 2/23/05, P2: 4/06; P3: 1/1/07
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wrotek
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Posted: Sun Feb 3rd, 2008 07:28 |
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This is an idea.
But I have been lurking recently into effects caffeine has on brain tryptophan and serotonin levels . And i have found some interesting data
Tea consumption in many cases is the main source of caffeine intake in humans. In the present study neurochemical and behavioural effects of long-term tea intake are monitored in rats. Long-term tea administration did not alter plasma tryptophan (TRP) but significantly attenuated brain TRP and 5-hydroxytryptamine (5-HT, serotonin) levels. Brain 5-hydroxyindole acetic acid (5-HIAA) was comparable in both tea-treated and control rats. An increase in home cage activity was observed after one week in rats taking tea as sole source of liquid, whereas no change on the activity was observed in an open field. Caffeinism has been associated with depression. The decreases of brain monoamine metabolism observed in present study are discussed as lowering of mood observed in tea or coffee consumers. PMID: 16414819 [PubMed]
Chronic caffeine alters the density of adenosine, adrenergic, cholinergic, GABA, and serotonin receptors and calcium channels in mouse brain.
http://tinyurl.com/24efzm
Chronic ingestion of caffeine by male NIH strain mice alters the density of a variety of central receptors. 2. The density of cortical A1 adenosine receptors is increased by 20%, while the density of striatal A2A adenosine receptors is unaltered. 3. The densities of cortical beta 1 and cerebellar beta 2 adrenergic receptors are reduced by ca. 25%, while the densities of cortical alpha 1 and alpha 2 adrenergic receptors are not significantly altered. Densities of striatal D1 and D2 dopaminergic receptors are unaltered. The densities of cortical 5 HT1 and 5 HT2 serotonergic receptors are increased by 26-30%. Densities of cortical muscarinic and nicotinic receptors are increased by 40-50%. The density of cortical benzodiazepine-binding sites associated with GABAA receptors is increased by 65%, and the affinity appears slightly decreased. The density of cortical MK-801 sites associated with NMDA-glutaminergic receptors appear unaltered. 4. The density of cortical nitrendipine-binding sites associated with calcium channels is increased by 18%. 5. The results indicate that chronic ingestion of caffeine equivalent to about 100 mg/kg/day in mice causes a wide range of biochemical alterations in the central nervous system.]
The amounts of caffeine mice ingest are very high, so probably changes in people consuming caffeine will be significantly smaller. Nonetheless, we can see a tendency which direction brain will try to adapt, that nicotinic receptor increase(maybe that is why caffeine potentates nicotine addiction) and serotonin receptors and benzodiazepine receptors also increase.
Last edited on Sun Feb 3rd, 2008 08:41 by wrotek
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Lyme reflux chronic pain fatigue depression 125D36 Ph1Sep05 Ph2Oct06 Ph3Apr07 homebound in low lux NoIRs 25D<7 Oct06
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Lottis
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Posted: Sun Feb 3rd, 2008 14:43 |
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Here is an interesting link:
MDR- and CYP3A4-mediated drug–herbal interactions
Dhananjay Pal and Ashim K. Mitra , 
http://www.ncbi.nlm.nih.gov/pubmed/16442130
/Lottis, following the thread and soon on the MP again
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HTN,LVH,CHF,arrhythmia,hypercholesterol,IBS? fibromyalgia? achne rosasea e.c.t.|15feb-07 init. 1,25D 37,5,|25-D 7,8(latest 15/2-07)| Ph1 29/5-08|Med;|carvedilol|Furix|Stesolid|Cymbalta|Mianserin| Magnyl|NoIR's|covered up|disabled|
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Dr Trevor Marshall
Research Team
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Posted: Sun Feb 3rd, 2008 16:44 |
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I tried St John's Wort once. It was a disaster
Maybe that points at CYP3A4 as taking over from CYP24 to degrade 1,25-D when the VDR isn't working right. Hmmm...
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jcwat101
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Posted: Sun Feb 3rd, 2008 17:25 |
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Those mice were certainly getting a lot. I am getting only 100 mg and I weigh far more than a kilogram
Also, I wonder if they were getting it around the clock. I am getting it in two small pulses and so my serum levels of caffeine should be pretty low by bedtime.
I also figure that there have been at least a few people on the MP who have improved or recovered who were drinking at least some caffeinated tea or a little coffee, and caffeine is not prohibited on the MP. And caffeine has been studied a great deal and is very widely used in the population. I think I read that well over 80% of the population consumes some caffeine-containing beverage regularly. Anyway, I have only begun recently, but so far, this small amount at about 7 am and noon seems to be working fine and seems to be helping with alertness and mood.
I did read that taking the birth control pill causes caffeine to have a longer half life (closer to 6-8 hours), so I figure when I am on the bc pill (as I am off and on), I should not take any after noon, as it will take longer to clear and I want it to mostly clear from my system (or much reduced anyway) by night time.
I'm not advocating a lot of caffeine and I would rather not use it at all. But, I think while I need a little more alertness while I still am killing the bacteria affecting my brain, some judicious use of caffeine in the No Doze is probably better than other alternatives (eg., prescription drugs). But I would not be in favor of high doses.
And I am also concerned about some of the ingredients we have discussed here and elsewhere that are found in soft drinks, coffee and even tea. Also, for people like myself, who are prone to food sensitivities, these drinks are not hypoallergenic enough, so that is why I like the caffeine in pill form.
Here are three links that I think cover the pros and cons pretty well:
Caffeine - Benefits and Risks
Health Benefits of Caffeine - Coffee, Caffeine and Weight Loss - Caffeine Burn
Pros and Cons of the Caffeine Craze
Anyway, that is my current view after several weeks of using the No Doze and we'll see if I change my opinion over time.
Joyce Waterhouse
PS The No Doze I get is 200 mg per tablet, which is equivalent to 2 cups of coffee. I take a 1/4 tablet when I wake up and 1/4 at around noon, like trying a cup of coffee in total.Last edited on Mon Feb 4th, 2008 01:10 by jcwat101
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20 yrs with CFS/FM/Lyme/IBS, food sensitivities; 1,25D/25D 8/04:64/11 1/05:22/6 9/05:1,25D=12 10/06:22/8, 4/07:25/<4 chewed Ben. 40mg q8h; Mod. P2: 2/23/05, P2: 4/06; P3: 1/1/07
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sunflower
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Posted: Sun Feb 3rd, 2008 17:56 |
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| i tried st john's wort for depression on 2 separate occasions and it was a disaster for me, too....i had so much brain fog i couldn't see straight . sun
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lyme,fibro,candida,allergies,gerd,osteopenia/ pain,fatigue,dizzy,memoryloss20+yrs/ celexa,vicodin,cal-mag/beni 40mg q6h 11-05/phase 3,8-06/1,25d=34 25d=36,18,17,10,13,5,7
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Joyful
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Posted: Mon Feb 4th, 2008 02:02 |
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Now there's an interesting theraputic probe for identifying those with 1,25D disregulation: trial St. John's Wort. 
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Lyme Babs? Bart? | 125D50 Ph1Jul07 ModPh2Sep07 Ph2Feb08 Ph3Aug08 | cal/mag lysine hydroxyzine valium | rarely leave house NoIRs cover up low lux home | 25D15 Oct08
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Caitiegirl
Member in Phase 2
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Posted: Mon Feb 4th, 2008 02:54 |
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Both Caitlin & Mom stopped sleeping and became very mean on St. John's Wort.
Mindy
BTW I have never been able to tolerate coffee or tea. Makes my back hurt horribly and meds won't help it.Last edited on Mon Feb 4th, 2008 02:58 by Caitiegirl
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Caitlin(17) lyme,seizures, myoclonus, dystonia, digestive, chronic headache, mental fog: 10/23/07 25D 36 1,25D 58, 1/18/08 25D 9.9 Cut sun/D 9/26/07 Benicar 10/25/07, NoIRs 10/29/07
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Linda J
Member in Phase 3
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Posted: Tue Feb 5th, 2008 05:26 |
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I became increasingly more and more irritable and angry on St. John's Wort, and I kept raising the dose, trying to compensate. When I finally got up to the maximum dose after about 9 months on it, and figured out it was the St. John's Wort that was responsible for my anger and irritability, I stopped it cold turkey. And ended up in a psychiatric ward two days later from being suicidal, with very disjointed and slow thinking processes, and a lot of confusion/brain fog and severe depression. That was also close to the start of my burgeoning health degredation back in 1999, and I had a lot of other health problems on top of that besides the emotional issues. The health problems had actually started long before I started using St. John's Wort. But it definately did NOT make me feel emotionally better, and my health problems began to snowball around that same period of time. And stopping it so abruptly also screwed my brain up royally, or at least started a chain reaction that caused me to develop other neurological problems.
However, I do know quite a few people who have symptoms of Th1 illnesses who claim that St. John's Wort made them feel better. So I'm not sure that using it as a probe to determine Th1 problems would work.
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VEZ R.N.
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Posted: Tue Feb 5th, 2008 05:37 |
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Maybe many of us with Th1 inflammatory diseases tried St. John's Wort with poor results. I tried it as well and it was a very bad experience.
VEZ
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lung gran x13 yrs neuro cardiac smp chronic cough joint pain TMJ pain tinnitus Factor V Leiden| armour probiotic|lowlux home NoIRs 6/30 Beni q4+prn 8/28 mino| 6/30 1,25D-58.3 25D-33.6| TSH-10.6 12/16/06 25D-9.6 TSH-8.63 8/06-25D=7|
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NickBowler
Member in Phase 3
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Posted: Tue Feb 5th, 2008 11:32 |
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http://www.dadamo.com/bloggers/ask/archives/00000058.htm
maybe a lot of you guys with bad reactions to SJW are blood type O
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Dr Trevor Marshall
Research Team
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Posted: Tue Feb 5th, 2008 12:34 |
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Nope, I am A+
Well, at least I was when I was sick. Haven't had the blood type tested recently...
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Linda J
Member in Phase 3
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Posted: Tue Feb 5th, 2008 19:38 |
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| No. I'm A-. What would blood type have to do with it, though?
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Lyme thyroiditis IBS MVP PTSD MCS 125D63 SAM-e Claritin probiotics psyllium silymarin magnesium 5htp GABA homebound low lux NoIRs 25D8 (Oct08)
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