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Russ
Member in Phase 3
| Joined: | Sat Mar 25th, 2006 |
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| Posts: | 213 |
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Posted: Tue Aug 19th, 2008 15:23 |
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| Yeah, I've heard that explanation before, though more in terms of just that they gnawed on bones rather than completely ate them. So yeah, if that's true, I guess they would have gotten a lot more calcium than I was thinking.
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Lyme/Borrelia, Connective Tissue Disease | May '06: 1-25D=59 25D=30 | Jul '06: Phase 1 | Aug '06 25D=16 | Oct '06 25D=6 | Nov '06: Phase 2 | Jul '07: Phase 3 | covering up & wearing NOIRs | no other meds or supplements
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Dr Trevor Marshall
Research Team
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Posted: Tue Aug 19th, 2008 16:17 |
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Calcium is found in leafy vegetables and seeds.
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JudyBeauty
Member in Phase 3
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Posted: Tue Aug 19th, 2008 19:29 |
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| I bet primitive man ate lots of insects which contain calcium. There are many cultures today that still eat insects and seem to enjoy them.
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CFS viral onset 1986 1-25D-53,25D-12 1/5 Noir's/D avoid July04/ Beni 3/22/05 40mg q6h Stop Benicar 4/23/05 Restart Beni 8/13/05,Valium
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wytnez
Member Advocate
| Joined: | Mon Nov 29th, 2004 |
| Location: | Texas USA |
| Posts: | 614 |
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Posted: Mon Sep 8th, 2008 23:54 |
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Take a look at this from the Parade Magazine from yesterday.
Vitamin D & Heart Disease
A report published in Archives of Internal Medicine suggests that a vitamin D deficiency can worsen heart disease. Researchers looked at levels of the vitamin among more than 3000 Austrians who were in the hospital for heart procedures. Seven years later, those who'd that the lowest vitamin D levels were most likely to have died in the interim. Another study, in the Journal of Cardiovascular Pharmacology, reports that vitamin D seems to help ward off heart failure-at least in rats.
"The sunshine vitamin" - technically is not a vitamin but a steroid hormone-gets activated when skin is exposed to sunlight. As little as 10 minutes of exposure daily may be enough to prevent low levels, also linked to broken bones, high blood pressure, cancer, and immune-system problems.
My purpose in sharing this is that I am surprised to finally see somewhere written that vitamin D is a steroid hormone besides from Dr. Marshalls papers. Looks like they may be trying to catch up. 
All the more reason for those who have chronic diseases to stay out of the sun so that the immune system is not suppressed.
Saj
Saj
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sarc lymph nodes. ph1 1/05,125D 33,25D 10,ph2 5/05,ph3 12/05,125D 21, 25D less than 7
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inge
Health Professional
| Joined: | Mon Sep 25th, 2006 |
| Location: | Oslo, Norway |
| Posts: | 164 |
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Posted: Wed Oct 8th, 2008 13:00 |
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In Marshall's Bioessays paper vitamin Ds are metioned as putative PXR-antagonists. While this may not be well documented, is there any doubt at all that 25-vit D and 1,25-vit D will affect CYP27A1, irrespective of the mechanism? To me it seems that this is well documented, but this is perhaps solely based on animal studies?
One more thing: Why is there a question mark between the two PXR bubbles in Figure 1?
Inge
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CFS/ME 125D64 25D12(dec 07) Ph1De06 daily lite exp NoIR use Ph2Mar07 ModPh2 Jun07 abx brkOct 07 r//t KFTs freq abx chg to control kidney IP Apr 08 phase 2 abx
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Dr Trevor Marshall
Research Team
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Posted: Wed Oct 8th, 2008 13:16 |
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There is now no doubt that the Vitamins D are PXR antagonists. I had correspondence with a wet-biology group who had tested Vitamin D as a PXR agonist, and it failed, so now we know the pathway - antagonism, which is the only one which makes sense, in any case.
The green question mark indicates that we really don't know what ligand activates PXR to transcribe CYP27A1, CYP24 or CYP3A4.
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