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jillian
Member in Phase 2
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Posted: Sun Dec 5th, 2004 16:08 |
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I found an article at MSNBC How much caffeine is too much? (http://www.msnbc.msn.com/id/6631177) that I thought was interesting for those of us with Th1 inflammatory disease. Here's two quotes (emphasis mine):
"Drinking more than four cups of coffee a day, however, may increase the risk of heart problems. In fact, a new study suggests that even two six-ounce cups of coffee a day may increase blood test values that measure inflammation."
"Earlier research seemed to show that caffeine increases the loss of calcium, raising the risk of osteoporosis. Even in a fairly recent study, women aged 65–77 who drank more than 300 milligrams (mg) of caffeine daily — about 18 ounces of regular coffee — showed greater bone loss over a three-year period than those who drank less. But the bone loss occurred only among a minority of women with an unusual variation in their cell vitamin D receptors."
Wouldn't I like to know what the "unusual variation in their cell vitamin D receptors" were!?! Hopefully one of these days clinical medicine will get it and start routinely testing D metabolites!
'til later,
Jillian
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PrimryDX-PulmoSarc79,FMS,CFIDS,etc,disabled93. AvoidD/Noirs Aug02. Oct02: 1,25D=42 NTfrzen; Apr05:25D=10. P1 Oct05-Feb06; ModP2C Feb-Nov06; P2 Nov14-Dec06; ModP2BSS Jan-Mar07; ModP2CBSS Mar07-. Noirs & total light control in house.
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TX Lyme Mom
Member
| Joined: | Mon Jul 12th, 2004 |
| Location: | Texas USA |
| Posts: | 476 |
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Offline
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Posted: Sun Dec 5th, 2004 23:09 |
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Jillian, I did a quick search of PubMed and I think I might have found the reference citation and abstract for the medical journal article upon which that statement was based about variations in vitamin D receptors in relation to caffeine consumption and osteoporosis. Here 'tis:
Am J Clin Nutr. 2001 Nov;74(5):694-700.
Comment in:
Caffeine intake increases the rate of bone loss in elderly women and interacts with vitamin D receptor genotypes.
Rapuri PB, Gallagher JC, Kinyamu HK, Ryschon KL.
Bone Metabolism Unit, Creighton University, School of Medicine, Omaha, NE 68131, USA. thiyyari@creighton.edu
BACKGROUND: The role of caffeine as a risk factor for bone loss is controversial. OBJECTIVE: Our goals were 1) to compare in both a cross-sectional study and a 3-y longitudinal study the bone mineral density (BMD) of postmenopausal women consuming high or low amounts of caffeine and 2) to study the interaction between caffeine intake, vitamin D receptor (VDR) polymorphism, and BMD in the longitudinal study. DESIGN: The results are derived from cross-sectional measurements of BMD in 489 elderly women (aged 65-77 y) and from longitudinal measurements made in 96 of these women who were treated with a placebo for 3 y. Changes in BMD were adjusted for confounding factors and were compared between groups with either low (< or =300 mg/d) or high (>300 mg/d) caffeine intakes and between the VDR genotype subgroups of the low- and high-caffeine groups. RESULTS: Women with high caffeine intakes had significantly higher rates of bone loss at the spine than did those with low intakes (-1.90 +/- 0.97% compared with 1.19 +/- 1.08%; P = 0.038). When the data were analyzed according to VDR genotype and caffeine intake, women with the tt genotype had significantly (P = 0.054) higher rates of bone loss at the spine (-8.14 +/- 2.62%) than did women with the TT genotype (-0.34 +/- 1.42%) when their caffeine intake was >300 mg/d. CONCLUSIONS: Intakes of caffeine in amounts >300 mg/d ( approximately 514 g, or 18 oz, brewed coffee) accelerate bone loss at the spine in elderly postmenopausal women. Furthermore, women with the tt genetic variant of VDR appear to be at a greater risk for this deleterious effect of caffeine on bone.
PMID: 11684540 [PubMed - indexed for MEDLINE] Last edited on Sun Dec 5th, 2004 23:11 by TX Lyme Mom
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Care-Giver & Lyme/CFIDS/MCS Support Group Leader; healthy (not a patient) so no D-level data for me
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