At levels above about 42 pg/ml, the 1,25-D (generated by Th1 inflammation) begins to stimulate bone osteoclasts, causing bone to be resorbed (dissolved) back into the bloodstream. This can lead to kidney stones.
It used to be thought that hypercalcemia was the only result of excess Vitamin D; we now know it is far more complex than that. Many normocalcemic sarcoidosis (Th1) patients have suffered from kidney stones and calcium deposition into the soft tissue as a result of excess levels of 1,25D in their tissue. Assuming the kidney stones are calcium oxalate (Doc can get them checked) they are characteristic of Th1 disease.
Minocycline is totally unrelated to kidney stone formation. If they are Calcium Oxalate, and most are, the stones develop when calcium is leached from your bones by high levels of 1,25-D and deposited in the soft tisues, including the kidneys. This is a Th1 disease-related process.
Kidney stones are not frequently reported by the MP cohort, as one aim of the MP is to lower the level of 1,25-D to values which do not leach the calcium from your bones.
If you have developed kidney stones since starting the MP, they are a result of months or years of development and not due to the effects of the MP. Your doctor will know how to help you through this crisis and the MP should prevent a reoccurence.
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