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Aussie Barb
Research Team
| Joined: | Thu Jul 22nd, 2004 |
| Location: | Australia |
| Posts: | 19445 |
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Online
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Posted: Sun Oct 30th, 2005 22:30 |
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I'm allergic to an antibiotic on the Protocol. Is there a substitute?
Your inability to tolerate antibiotics previously does not mean that you will be unable to take the MP antibiotics. Keep in mind that the effectiveness of the antibiotics against the bacteria that are driving your Th1 inflammation means that you will get an immunopathologic reaction. This is to be expected and should not be interpreted as a side effect, adverse reaction or intolerance.
Many people have reported on this forum about their supposed 'allergy' to certain antibiotics. Experience has taught us that folks with Th1 inflammation who have had these so-called reactions, have actually had a normal immune system reaction.
The paper Observations of Jarisch-Herxheimer Reaction in Sarcoidosis Patients applies to all Th1 illnesses. says in part: JHR is sometimes mistaken for a “hypersensitivity reaction” or even the cause of a related, (probably pre-existing) disease such as lupus. Pruritus, hives and rash induced by JHR can be misdiagnosed as an allergic (Th2) reaction to the antibiotic.
The Benicar blockade helps manage those reactions. Many people report previous 'allergic' reactions to MP antibiotics but go on to take them successfully using the cautious MP ramping schedule.
The MP antibiotics have been chosen carefully for their excellent safety profile as well as effectiveness against intracellular bacteria. They are used in low doses and ramped up slowly to avoid severe immunopathologic reactions.
Many MP patients who thought they were allergic to the MP antibiotics have found that the 'allergy' was really a immunopathologic reaction. We understand your reluctance to take a medication that is likely to make you feel ill periodically. These symptoms will be similar to your disease symptoms. But it is the only path to recovery.
Beta-lactam antibiotics
Beta-lactams antibiotics, like penicillin, can kill some Cell Wall Deficient bacteria which are moving from cell to cell. Therefore, a reaction to these antibiotics could be an immunopathologic reaction, especially if the reaction was mild. However, true allergies do exist to the beta-lactam antibiotics and you should follow the advice of your physician regarding their further use.
Start with a small dose
Anyone who is nervous about taking an antibiotic to which they have a suspected allergy, should start with a very small dose. If you are extremely nervous about an allergic reaction, ask your doctor if you can take it while at the outpatient area of your hospital where help would be available should you need it.
Laboratory tests can help differentiate between a immunopatholgic reaction to microbial toxins and an allergic reaction to medication. WBCs and 1,25-dihydroxyvitamin-D will be elevated in an immunopathologic reaction. But a marked increase in eosinophils (about 30%) or the presence of specific antibodies is an indication of an allergic reaction.
Molecular size
"Review my presentation on antibiotics at Chicago, where I argued that the size of antibiotic molecules is too small for true allergy to develop, as they are too small to catalyze the formation of antibodies. Consequently, they are typically recognized by innate immunity, and not by acquired immmunity.
Now, my arguments can (of course) be challenged. But nobody has done that yet  "
..Trevor..
See Is it an allergy or is it an immune system reaction?
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Barb: Dx Inflammatory Disease Endocrine Imbalance 2003| 24+ years not Dx| ABCofMP
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Meg Mangin R.N.
Research Team (on leave)
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Posted: Wed Nov 29th, 2006 01:05 |
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(filelink)
Does minocycline have side effects or cause lupus?
The reports that Minocycline can induce lupus are laughable. Exactly how does a complex immune disease arise from the actions of a bacteriostatic antibiotic? Such a suggestion is ridiculous. The same goes for the suggestion that minocycline induces autoimmune hepatitis. Show us the beef, please - the molecular mechanisms.
Remember that it was not too long ago that the majority of physicians agreed with the statement below. That consensus didn't make it any more correct...
In order to comprehend the discoveries springing from the cracking of the genome, today's physicians need to have a good understanding of modern science. It is tough for us to expect this, as many have not been even taught the basics of molecular biology. The alternative is for them to listen to those who are accepted as well grounded in science. Many physicians find that just as hard to swallow, as the profession trains them to present medicine, and its practitioners, to the public as infallible.
~Trevor
Side effects
Once you understand the immunopathology resulting from killing these Th1 pathogens, all these so-called side-effects are shown up for what they are - Immunopathology - and they disappear as you get rid of he pathogens.
..Trevor..
See also:
I'm allergic to an antibiotic on the Protocol. Is there a substitute?
Lupus In 'Overlap' With Other Connective Tissue Diseases
Last edited on Fri Dec 21st, 2007 17:24 by Meg Mangin R.N.
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Nothing contained in this site is or should be considered, or used as a substitute for, medical advice, diagnosis or treatment by your physician.
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