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Markt9452
Member in Phase 3
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Posted: Wed Feb 20th, 2008 22:52 |
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Benicar posts
MP meds: Benicar 40mg q6h, Minocycline 25 mg every 48 hours - Day 1
Non-MP palliative med use: None
Natural Light exposure: 1.5 hours per day with NOIRS covered up
Symptoms:
Brain Fog - 6.5
Fatigue - 6.5
Skin - 3
Tinnitus - 3
Light sensivity - 5.5
Red eyelids - 4
Memory Loss - 5
Swelling of Mastoid - 2
Joint Pain - 3
Twitching - 3
Irritability - 5
Vertigo - 4
Headaches - 3
Comments: First Dose of Mino at 18:00 Feb 20 2008 after 1 week on Benicar 
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Th1 Inflammation Lyme vertigo fatigue brain fog skin lesions tinnitis 125D20 D2510 Ph1Feb08 Ph2Apr08 daily lite exp covered up NoIRs
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Meg Mangin R.N.
Research Team (on leave)
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Posted: Thu Feb 21st, 2008 04:05 |
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Thanks for letting us know you have started minocycline. Please review the information threads pinned to the top of this forum so you will be able to independently locate answers to frequently asked questions. See What should I know about Minocycline?
During Phase One you will learn to identify your immune response symptoms and manage all aspects of the MP....avoiding light and vitamin D, getting adequate rest, pacing activities, eating well, etc. It may take 2 weeks to feel the effects of minocyline when you begin taking it.
Until you know, it is best to err on the side of caution. Stay at each subsequent dose level for a minimum of 3-4 doses with tolerable symptoms at all times before increasing unless experience tells you that an increase would dampen intolerable symptoms. An increase in any symptom that correlates with MP therapy is due to immunopathology. This can be controlled by careful management of MP medications and palliative meds as needed.
Let know how it goes.........
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Nothing contained in this site is or should be considered, or used as a substitute for, medical advice, diagnosis or treatment by your physician.
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Markt9452
Member in Phase 3
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Posted: Thu Feb 21st, 2008 15:49 |
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MP meds: Benicar 40mg q6h, Minocycline 25 mg every 48 hours - Phase 1 for 17 hours
Non-MP palliative med use: None
Natural Light exposure: 1.5 hours per day with NOIRS covered up
Symptoms:
Brain Fog - 6.5
Fatigue - 6.5
Skin - 3
Tinnitus - 3
Light sensivity - 5.5
Red eyelids - 4
Memory Loss - 5
Swelling of Mastoid - 2
Joint Pain - 3
Twitching - 3
Irritability - 5
Vertigo - 4
Headaches - 3
Comments: Mino response almost immediate. Feels like a cold without the mucous and is tolerable - expecting more IP as level of mino decreases
Noted
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Th1 Inflammation Lyme vertigo fatigue brain fog skin lesions tinnitis 125D20 D2510 Ph1Feb08 Ph2Apr08 daily lite exp covered up NoIRs
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Markt9452
Member in Phase 3
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Posted: Thu Feb 28th, 2008 02:47 |
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MP meds: Benicar 40mg q6h, Minocycline 25 mg every 48 hours - Phase 1 for 1 week
Non-MP palliative med use: None
Natural Light exposure: 1 hour per day with NOIRS covered up housebound
Symptoms:
Brain Fog - 5
Fatigue - 5
Skin - 2.5
Tinnitus - 3
Light sensivity - 5.5
Red eyelids - 3.5
Memory Loss - 4
Swelling of Mastoid - 2
Joint Pain - 2
Twitching - 3
Irritability - 4
Vertigo - 4
Headaches - 3
Comments: Monocycline IP is decreasing after 1 week at 25mg/48 hrs - will increase mino to 50mg/48 hours to increase IP
Exposure of the eyes to any kind of radiation corresponds to vertigo, memory loss/confusion, headaches, red eyes, brain fog, fatigue
Minocycline herx is worse after 24 hours causing cold sweats, shakes, cold-like symptoms without mucous.
Noticable improvement in the jaw/mastoid, inner ear and skin.
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Th1 Inflammation Lyme vertigo fatigue brain fog skin lesions tinnitis 125D20 D2510 Ph1Feb08 Ph2Apr08 daily lite exp covered up NoIRs
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Meg Mangin R.N.
Research Team (on leave)
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Posted: Thu Feb 28th, 2008 05:46 |
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You are responding as expected to pulsed minocycline.....
Based on your report, you could increase mino to 50mg. See How To Identify Immunopathology (Herx) and How to assess symptoms. Finding the low enough/high enough dose level of minocycline that works for you is part of the experience gained throughout the MP journey. You will gain confidence in your knowledge of the actions of your immune response and when to increase as you get more experience in independently adjusting the MP meds.
Stay at each subsequent dose level for a minimun of 3-4 doses with tolerable symptoms at all times before increasing unless experience tells you that an increase would dampen intolerable symptoms.
Let us know how it goes........
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Nothing contained in this site is or should be considered, or used as a substitute for, medical advice, diagnosis or treatment by your physician.
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Markt9452
Member in Phase 3
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Posted: Mon Mar 3rd, 2008 18:00 |
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MP meds: Benicar 40mg q6h, Minocycline 50 mg every 48 hours - Phase 1 for 2 weeks
Non-MP palliative med use: None
Natural Light exposure: 1 hour per day with NOIRS covered up
Symptoms:
Brain Fog - 5
Fatigue - 5
Skin - 2
Tinnitus - 3
Light sensivity - 5
Red eyelids - 3
Memory Loss - 4
Swelling of Mastoid - 2
Joint Pain - 2
Twitching - 2
Irritability - 3
Vertigo - 3.5
Headaches - 2
Comments:Expected increase in IP after increasing Mino to 50mg q48h. Lesions around eyelids dissapearing. Decreased light sensitivity. Eyelids less red. Decrease in twitching, irritability vertigo and headaches. General increase in quality of eyesight, resolution, color and peripheral vision. Lot's of mild lower abdominable pain in liver and pancreas area associated with vertigo and fatigue. Healing sensation on shins, forehead, back of skull and mastoid area.
Plan:Stay at 50mg mino q48h for another week and reassess IP.
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Th1 Inflammation Lyme vertigo fatigue brain fog skin lesions tinnitis 125D20 D2510 Ph1Feb08 Ph2Apr08 daily lite exp covered up NoIRs
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Meg Mangin R.N.
Research Team (on leave)
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Posted: Mon Mar 3rd, 2008 20:11 |
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In phase one, it's a good idea to experiment with minocycline and Benicar to see how they work for you. Extend the mino dosing schedule to every 72 hours to see if symptoms are dampened or if more immunopathology is provoked. And conversely, when symptoms peak (not necessarily intolerable), reduce or stop the mino dose to see if that dampens symptoms. You could also try taking lower dose minocycline every six or 12 hours to see if mino has an anti-flammatory effect for you.
When a symptom approaches intolerable try an extra Benicar, both oral and sublingual. If that is not effective, increase to every four hours around the clock (set an alarm) to see if that measure is effective to quell the symptom. The resulting information can be added to your personal tool kit.
You will gain experience adjusting MP meds to maintain tolerable immune system reactions. This skill will carry you smoothly through the protocol; when you have learned to manage on a day-to-day basis, you will be equipped to handle a crisis if it occurs.
Keep up the good work...........
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Nothing contained in this site is or should be considered, or used as a substitute for, medical advice, diagnosis or treatment by your physician.
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Markt9452
Member in Phase 3
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Posted: Tue Mar 4th, 2008 20:08 |
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MP meds: Benicar 40mg q6h, Minocycline 50 mg every 48 hours - Phase 1 for 2 weeks
Non-MP palliative med use: None
Comment: Monocycline results in maximum IP at around 5 and 30 hours. At 48 hours the IP is less but still present. This is very consistant.
Question: Is there any advantage in maintaining the low tissue concentration of minocycline at 48 hours by increasing to 72 hours given the fact that herx is still occurring after 48 hours?
I have not suffered intolerable IP yet so I am not trying to increase or decrease the herx but rather trying to determine the optimal tissue concentration of minocycline after 48 hours in terms of killing bacteria.
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Th1 Inflammation Lyme vertigo fatigue brain fog skin lesions tinnitis 125D20 D2510 Ph1Feb08 Ph2Apr08 daily lite exp covered up NoIRs
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Chris
Member Advocate
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Posted: Tue Mar 4th, 2008 22:33 |
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Is there any advantage in maintaining the low tissue concentration of minocycline at 48 hours by increasing to 72 hours given the fact that herx is still occurring after 48 hours?
This can vary a lot. There were times I ran to 72 hours to get a bit more herx when the herx was mild, or the full dose didn't seem to taper off fast enough to provoke killing in the 48 hours, and there were times when 48 was a must, as the next dose of antibiotic was needed to quell the not-very-mild-at-all herx as the my body got very competent at killing bugs by itself.
Now's a good time (low herx) to see what happens if you miss a day. Just don't expect the same result at other dose levels or other antibiotics, or other stages in the process. It's your body, and your unique problems. Get used to being proactive in figuring out what works and doesn't for you. And don't exceed the guidelines; they are there for a reason (max dose, no supplements, light discipline, etc.).
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sarcoid diagnosed 1991, probably started 1983
D25/1,25: Mar04 17/80, Sep04 12/50, Nov04 8/23, Jan05 9/39 May05 6/27; in phase3; fevers, muscle pain, tinnitus, depression, mental-fog, IBS, carpal-tunnel, fatigue, osteopenia
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Markt9452
Member in Phase 3
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Posted: Mon Mar 10th, 2008 21:39 |
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Thanks for the info. Chris - good stuff
MP meds: Benicar 40mg q6h, Minocycline 50 mg every 48 hours - Phase 1 for 3 weeks
Non-MP palliative med use: None
Natural Light exposure: 1 hour per day with NOIRS covered up
Symptoms:
Brain Fog - 5
Fatigue - 5
Skin - 2
Tinnitus - 3
Light sensivity - 4
Red eyelids - 3
Memory Loss - 4
Swelling of Mastoid - 1.5
Joint Pain - 3
Twitching - 3
Irritability - 3
Vertigo - 3.5
Headaches - 2
Comments: I am experiencing quite a bit of sensations all over my body - I wouldn't call it pain - It just feels like things are changing. Lots of twitching lower back above kidneys, Sensations in all wisdom teeth sockets, mastoid, legs, lower abdomen, ears, sinuses, eyes, skin. Some bilateral pain top of feet just behind little toe.
Joint pain in knee has increased particulary in area where arthroscopic surgery was done - as expected. Lots of itchy skin. Things generally going well - herx comes and goes. Sleeping a lot. 48 hours seems to be the perfect amount of time for mino. I am herxing and it is making me feel better - kind of hard to describe but as expected. I am finding it harder to find the right words sometimes and twitching is a bit worse - but again - this is as expected. Vision has profoundly improved in every way.
Plan:I'm going to go to minocycline 75mg q48h within the next couple of days.
Thank You for making a difference in my life.
Mark
Last edited on Mon Mar 10th, 2008 21:41 by Markt9452
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Th1 Inflammation Lyme vertigo fatigue brain fog skin lesions tinnitis 125D20 D2510 Ph1Feb08 Ph2Apr08 daily lite exp covered up NoIRs
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Meg Mangin R.N.
Research Team (on leave)
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Posted: Tue Mar 11th, 2008 03:06 |
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Thanks for letting us know you will be ramping to 75mg mino....
It is important that you become independant in medication management and gain experience by adjusting MP meds using your personal tool kit to manage immune system reactions. This skill will carry you smoothly through the protocol.
If symptoms are approaching intolerable, assess your natural light exposure, assess your symptoms and use your personal tool kit to be sure symptoms are not due to other factors besides immunopathology (sun exposure, lack of rest, exercise, diet, etc) that can be modified to reduce symptoms asap.
As always, if our information does not provide the answer for you, please ask before you take action. Carry on.........
____________________
Nothing contained in this site is or should be considered, or used as a substitute for, medical advice, diagnosis or treatment by your physician.
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Markt9452
Member in Phase 3
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Posted: Tue Mar 18th, 2008 01:54 |
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MP meds: Benicar 40mg q6h, Minocycline 75 mg every 48 hours - Phase 1 for 26 days
Non-MP palliative med use: None
Natural Light exposure: In the house with low light
Symptoms:
Brain Fog - 5.5
Fatigue - 5
Skin - 2
Tinnitus - 3
Light sensivity - 4
Red eyelids - 4
Memory Loss - 4.5
Swelling of Mastoid - 1.5
Joint Pain - 3
Twitching - 3
Irritability - 3
Vertigo - 3.5
Headaches - 2
Comments: I am doing OK with mino 75mg q48h. Some increase of neurological symptoms. Sleeping a lot.
Plan:I'm going to go to minocycline 100mg q48h within the next couple of days.
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Th1 Inflammation Lyme vertigo fatigue brain fog skin lesions tinnitis 125D20 D2510 Ph1Feb08 Ph2Apr08 daily lite exp covered up NoIRs
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VEZ R.N.
Board Staff
| Joined: | Fri May 19th, 2006 |
| Location: | Ohio, USA |
| Posts: | 2469 |
| Status: |
Offline
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Posted: Tue Mar 18th, 2008 03:52 |
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Thanks for the update M.
From your report it looks like you are managing well. Your plan sounds like a good one. You are doing a nice job.
Best Regards, VEZ
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lung gran x13 yrs neuro cardiac smp chronic cough joint pain TMJ pain tinnitus Factor V Leiden| armour probiotic|lowlux home NoIRs 6/30 Beni q4+prn 8/28 mino| 6/30 1,25D-58.3 25D-33.6| TSH-10.6 12/16/06 25D-9.6 TSH-8.63 8/06-25D=7|
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Markt9452
Member in Phase 3
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Posted: Mon Mar 24th, 2008 19:10 |
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MP meds: Benicar 40mg q6h, Minocycline 100 mg every 48 hours - Phase 1 for 33 days 
Non-MP palliative med use: None
Natural Light exposure: In the house with low light 
Symptoms:
Brain Fog - 6
Fatigue - 5
Skin - 2
Tinnitus - 3
Light sensivity - 5
Red eyelids - 4
Memory Loss - 5
Swelling of Mastoid - 1.5
Joint Pain - 3
Twitching - 3
Irritability - 3
Vertigo - 4
Headaches - 3
Comments: 100 Mg Mino is packing quite a punch. Lots of activity in the jaw and ears. Some increase in symptoms. Plenty of herxing. Vertigo is more frequently the objective kind. Urine is greenish and cloudy. Symptoms much worse at night 
Thank You - Mark
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Th1 Inflammation Lyme vertigo fatigue brain fog skin lesions tinnitis 125D20 D2510 Ph1Feb08 Ph2Apr08 daily lite exp covered up NoIRs
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Meg Mangin R.N.
Research Team (on leave)
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Posted: Mon Mar 24th, 2008 22:55 |
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If symptoms are approaching intolerable, assess your natural light exposure, assess your symptoms and use your personal tool kit to be sure symptoms are not due to other factors besides immunopathology (sun exposure, lack of rest, exercise, diet, etc) that can be modified to reduce symptoms asap.
The recommended first step when symptoms have gone past tolerable is to increase Benicar. Do not wait. Take an extra oral 40mg immediately. A hot drink (sugar-free chocolate or weak tea) will help the pill reach the stomach quickly.
Chewing the tablet and placing it under the tongue will promote faster absorption and quicker symptom relief. See How to make Benicar act faster.
If an extra oral or sublingual dose of Benicar does not work, do not assume that increasing Benicar to every 3-4 hours will not work.
If intolerable symptom/s persist, increase oral 40mg Benicar to every three or fours hours around the clock (set an alarm and use a dosette to avoid error). Continue until symptoms are tolerable.
During a 'crisis' situation, an extra 20mg of Benicar may be taken sublingually with each every three or four hour oral Benicar dose. This is especially important for folks who have GI tract inflammation.
If increasing Benicar does not reduce intolerable symptoms, adjust mino to dampen symptoms.......take an extra dose, skip a dose, or take low-dose, high-frequency minocycline.
As always, if our information does not provide the answer for you (be sure to click on all the links), please ask before you take action.
Increase fluids and assess urine for color and clarity.
Continue all supportive measures....light avoidance, rest, good nutrition, adequate hydration, palliative meds as needed.
Let us know how you are doing.....
____________________
Nothing contained in this site is or should be considered, or used as a substitute for, medical advice, diagnosis or treatment by your physician.
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Markt9452
Member in Phase 3
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Posted: Mon Mar 31st, 2008 23:42 |
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MP meds: Benicar 40mg q6h, Minocycline 100 mg every 24-72 hours - Phase 1 for 40 days
Non-MP palliative med use: None
Natural Light exposure: In the house with low light
Symptoms:
Brain Fog - 5
Fatigue - 4
Skin - 2
Tinnitus - 3
Light sensivity - 4
Red eyelids - 3
Memory Loss - 4.5
Swelling of Mastoid - 1.5
Joint Pain - 4
Twitching - 3
Irritability - 3
Vertigo - 3.5
Headaches - 3
Comments: Taking mino at 100mg q72h today after some decrease in herx and Th1 symptoms at q24h. White round lesions on eyelids get worse and then disappear overnight. Nice.
The necklace of red and white spots and splotchy red skin around my collarbone area is almost gone now. Very Nice.
Lots of pain in the Jaw behind wisdom tooth socket - I believe the connective tissue and bone is heavily infected there because there is less blood supply. This is very close to my ear, eustacian tube, mastoid area. I believe this started long before the tooth was extracted. X-rays show nothing. The pain is obviously a good thing.
Plan: I will be taking mino 100mg q24-72h in order to maximixe herx within tolerable limits. I'm pretty familiar with what the mino does to me now and feel very confidant about managing IP.
Question: I have a lot of pain in the armpit area but only when I'm laying in bed at night. The pain leads to my arms falling asleep as if there wasn't enough circulation. It's very strange. I can't tell if it's my lympth nodes, a nerve, the joint or a restriction of blood. Or all of the above? This got really noticable after I started removing vitD foods a few months ago and before the MP. It got better after the Benicar but after I started the mino it is getting worse.
I end up sleeping in the strangest positions just to stop my arms from falling asleep. On my side with one arm on top of my head. On my stomach in a praying mantis kinda position with my arms tucked underneath. What ends up happening is that one arm falls asleep and then I roll over to give it a break (but then the other one falls asleep) - so I'm constantly having to shift positions all through the night - 
I'm not particularly worried about it as I am sure as it's part of my own unique illness and healing process. I just thought I'd mention it just in case you have seen that before.
If I had to guess I would say it has something to do with inflammation on the nerves in that location as opposed to my other ideas.
Thank You Meg, Vez and Chris
Rock On Dr M - Mark
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Th1 Inflammation Lyme vertigo fatigue brain fog skin lesions tinnitis 125D20 D2510 Ph1Feb08 Ph2Apr08 daily lite exp covered up NoIRs
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Meg Mangin R.N.
Research Team (on leave)
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Posted: Tue Apr 1st, 2008 01:59 |
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Mark, based on your report, it looks like you should be thinking about progressing to phase two. Please see How do I know if I'm ready for phase two? for information on how to request the questionnaire. Before you proceed to phase two, ask your doctor about the tests you need to monitor your progress on the MP.
Pins/needles or numbness in extremities suffered during sleep is thought to be due to lymphatic system inflammation and reduced lymph circulation when in a prone position leading to interference with nerve function. Moving the extremity resolves the sensation quickly. See Will the MP treat paresthesia and neuropathy?
Keep up the good work..........
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Nothing contained in this site is or should be considered, or used as a substitute for, medical advice, diagnosis or treatment by your physician.
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Markt9452
Member in Phase 3
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Posted: Sun Apr 6th, 2008 20:18 |
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MP meds: Benicar 40mg q6h, Minocycline 100 mg every 48-72 hours - Phase 1 for 46 days
Non-MP palliative med use: None
Natural Light exposure: In the house with low light
Symptoms:
Brain Fog - 4
Fatigue - 4
Skin - 2
Tinnitus - 2.5
Light sensivity - 3
Red eyelids - 3
Memory Loss - 4.5
Swelling of Mastoid - 1
Joint Pain - 3
Twitching - 2.5
Irritability - 3
Vertigo - 3.5
Headaches - 3
Comments: I am now taking Mino 100mg alternating between 48 and 72 hours. The immune response is quite different depending on whether the last dose was 48 or 72 hours previous.
I have an appointment with my Doc on the 14th of April. I will discuss the phase II antibiotics and the potential for increased neuropathy with him. I will also discuss relevant progress monitoring tests.
The paresthesia has gotten better this week and I believe it is related to IP from the Mino. The paresthesia is worse as the level of mino decreases.
Thank You Meg and the Marshall Protocol Research Team....
Mark
Last edited on Sun Apr 6th, 2008 20:49 by Markt9452
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Th1 Inflammation Lyme vertigo fatigue brain fog skin lesions tinnitis 125D20 D2510 Ph1Feb08 Ph2Apr08 daily lite exp covered up NoIRs
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Markt9452
Member in Phase 3
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Posted: Mon Apr 7th, 2008 18:12 |
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Comments: Experiencing some bright red rectal bleeding this morning after eating garlic the night before. I am using some links I have found on the MP forum to evaluate. Apparantly this is not unusual given the circumstances and is not a surprise.
Also I ate a piece of Quiche Lorraine yesterday . This was my first deviation from the MP diet in months. I have now learned my lesson. 
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Th1 Inflammation Lyme vertigo fatigue brain fog skin lesions tinnitis 125D20 D2510 Ph1Feb08 Ph2Apr08 daily lite exp covered up NoIRs
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Meg Mangin R.N.
Research Team (on leave)
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Posted: Mon Apr 7th, 2008 22:05 |
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Bright red bleeding usual indicates local trauma. Please see I’ve developed rectal bleeding. What should I do?
Let us know how you are doing........
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Nothing contained in this site is or should be considered, or used as a substitute for, medical advice, diagnosis or treatment by your physician.
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